Overview Testicular torsion is a urological emergency caused by twisting of the spermatic cord, leading to acute interruption of blood flow to the testis and rapid ischemia. It most commonly occurs in adolescents (peak 12–18 years) but can occur at any age, including neonates. The incidence is approximately 1 in 4,000 males under 25 years. Early […]

Overview Snapping Hip Syndrome (SHS) is characterized by an audible or palpable “snap” around the hip during motion; it may be painless or painful and can be unilateral or bilateral. Prevalence estimates suggest up to ~5–10% of the general population may experience snapping to some degree, with higher rates in dancers and athletes who work […]

Overview Prostatitis refers to a spectrum of conditions involving inflammation of the prostate gland, ranging from acute bacterial infection to chronic pelvic pain syndromes. It is a common urological condition affecting men of all ages, particularly those aged 30–50 years. The National Institutes of Health (NIH) classifies prostatitis into four categories: acute bacterial, chronic bacterial, chronic […]

Overview VEXAS syndrome is a late-onset, adult autoinflammatory disease caused by acquired somatic mutations in the UBA1 gene, leading to dysregulated innate immunity, systemic inflammation, and overlapping haematologic and rheumatologic manifestations.  VEXAS stands for Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic. It predominantly affects older males due to its X-linked nature and typically presents with refractory […]

Overview Osteonecrosis of the hip, usually referring to osteonecrosis of the femoral head (ONFH), is a progressive disorder caused by compromised subchondral blood supply leading to death of osteocytes and marrow elements, failed structural repair, subchondral fracture, femoral head collapse, and eventually secondary hip osteoarthritis.[1-4]  It most often affects younger to middle-aged adults, commonly between […]

Overview Amyloidosis is a disorder in which misfolded proteins aggregate into insoluble beta-pleated sheet fibrils and deposit extracellularly in tissues, leading to progressive organ dysfunction. It may be systemic or localized.  In current practice, the most clinically important systemic forms are AL (light-chain), AA (serum amyloid A), and ATTR (transthyretin; hereditary or wild-type). The phenotype […]

Overview Behçet’s syndrome is a chronic, relapsing, multisystem inflammatory disorder and variable-vessel vasculitis characterized classically by recurrent oral ulcers, genital ulcers, ocular inflammation, and skin lesions. It can also involve the joints, vessels, nervous system, and gastrointestinal tract.  The disease is most prevalent along the historic “Silk Road” region, including Turkey, the Middle East, and […]

Overview Chronic spontaneous urticaria (CSU) is a mast-cell–driven skin disorder defined by recurrent wheals (hives), angioedema, or both for >6 weeks without a specific external trigger, with a point prevalence around 0.5–1% and a female predominance; median disease duration is ~2–5 years, but a subset persists longer and markedly impairs quality of life and work […]

Overview Anaphylaxis is a severe, systemic hypersensitivity reaction that is rapid in onset and potentially fatal, most often triggered by foods, medications, or venom; global incidence is ~50–112 per 100,000 person-years with rising emergency presentations in many regions, including Australia [1,2,4].  Mortality is low but non-trivial and is driven by airway obstruction, severe bronchospasm, or […]

Overview Adult Onset Still’s Disease (AOSD) is a complex multisystemic autoinflammatory disease characterised by recurrent episodes of spiking fever (> 39–40°C), pink–salmon transient skin rash, and the presence of arthralgia or polyarthritis. First described by Eric Bywaters in 1971 it closely resembles systemic onset juvenile idiopathic arthritis (Still’s disease). Pathophysiology AOSD is a polygenic and […]

Overview Shoulder impingement syndrome, now more commonly referred to as subacromial pain syndrome (SAPS), is one of the most frequent causes of shoulder pain. It accounts for ~40–65% of shoulder complaints in primary care and sports medicine settings. It occurs due to mechanical compression of the rotator cuff tendons (most commonly supraspinatus) and subacromial bursa […]

Overview Scaphoid fracture is the most common carpal bone fracture, accounting for ~60–70% of all carpal fractures. It occurs most frequently in young adults (15–40 years) following a fall on the outstretched hand (FOOSH). The scaphoid’s tenuous blood supply predisposes to non-union and avascular necrosis, especially in proximal fractures. Early recognition is essential as delayed […]

Overview Chronic compartment syndrome (also known as chronic exertional compartment syndrome or exercise induced compartment syndrome) is an exertional condition in which repetitive activity causes transiently elevated pressure within a closed myofascial compartment, leading to ischemic pain, tightness, and sometimes neurologic symptoms that predictably begin with exercise and abate with rest. It most often affects […]

Overview Anterior cruciate ligament (ACL) tear is one of the most common knee injuries, particularly in young athletes involved in pivoting sports (soccer, basketball, skiing). ACL injuries account for ~50% of all knee ligament injuries, with an incidence of ~68 per 100,000 annually, more common in females due to anatomical and biomechanical risk factors. ACL […]

Overview Achilles tendinopathy & rupture are common causes of posterior ankle pain and disability, particularly in active adults. Tendinopathy presents with chronic pain, stiffness, and impaired function, while rupture is an acute injury characterised by a sudden “pop” and loss of plantarflexion power. Achilles tendon injuries are increasingly prevalent due to sports participation, with rupture […]

Overview Toxic Multinodular Goitre (TMNG) is the second most common cause of hyperthyroidism caused by a long-standing goitre and/or iodine deficiency which results in an increased risk of mutation and consequent TSH-independent autonomic function of thyroid nodules to produce excess thyroid hormones. Common clinical manifestations include hyperthyroidism and a painless thyroid goitre with palpable nodules. […]

Overview Cryoglobulinaemic vasculitis is an immune complex–mediated small to medium vessel vasculitis caused by circulating cryoglobulins—immunoglobulins that precipitate below 37 °C and redissolve on warming. These immune complexes deposit in vessel walls, activate complement (typically with marked C4 consumption), and drive leukocytoclastic vasculitis. “Mixed” CV (types II and III) is most often linked to hepatitis […]

Overview Post‑splenectomy immunodeficiency refers to the increased susceptibility to infection following removal (or functional loss) of the spleen. The spleen plays a critical role in filtering bloodborne pathogens, especially encapsulated bacteria, and in mounting both innate and adaptive immune responses. Loss of splenic function leads to impaired opsonisation, reduced IgM production, and defective clearance of […]

Overview Sarcoidosis is a multisystem granulomatous disease of unknown cause, characterised by the formation of non‑caseating granulomas in affected organs. Pulmonary involvement occurs in ~90% of patients, making it the most common manifestation. Global prevalence varies widely (e.g., 3.7/100,000 in Japan vs. 28.2/100,000 in Finland), with higher rates in Black Americans and Northern Europeans. Peak […]

Overview Chronic lower limb ischemia can be classified using the Fontaine classification: Grades III and IV are classified as Critical Limb Ischemia. Intermittent claudication is a type of chronic lower limb ischemia that presents with muscle pain on exercise and is relieved on rest2. It affects 4% of people over 55, mostly men1. Up to […]

Overview Acute limb ischaemia refers to any sudden decrease in limb perfusion that causes a potential threat to viability. It is associated with pain, motor and sensory loss, and cold sensation. It affects one in about 6000 of the population1 and is more common in the lower limb, with less than 17% of cases affecting […]

Overview Rheumatoid pleural effusion (RPE) is an uncommon extra‑articular manifestation of rheumatoid arthritis (RA), occurring in ~2–5% of patients, more often in middle‑aged men with high rheumatoid factor (RF) titres, despite RA being more common in women. It typically presents during active disease or in patients with rheumatoid nodules, but can occasionally precede joint symptoms. […]

Overview Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a serious extra-articular manifestation of RA, affecting up to 10% of RA patients clinically, though subclinical involvement may be present in up to 60% on HRCT. It typically presents in the 5th–6th decade, with a male predominance and is a leading cause of RA-related mortality. The most […]

Overview Sjögren’s-associated interstitial lung disease (Sjögren’s-ILD) is a significant extra-glandular manifestation of primary Sjögren’s disease (pSS), occurring in ~9–20% of patients clinically, with subclinical involvement detectable in up to 50% on HRCT. It may precede sicca symptoms or develop late in the disease course. The most common ILD pattern is nonspecific interstitial pneumonia (NSIP), followed […]