Medical science, drawn into focus.

Sjögren’s-Associated Interstitial Lung Disease 

Overview Sjögren’s-associated interstitial lung disease (Sjögren’s-ILD) is a significant extra-glandular manifestation of primary Sjögren’s disease (pSS), occurring in ~9–20% of patients clinically, with subclinical involvement detectable in up to 50% on HRCT. It may precede sicca symptoms or develop late in the disease course. The most common ILD pattern is nonspecific interstitial pneumonia (NSIP), followed…

Pre-operative Care

Overview Definition Perioperative Management refers to the period of time extending from the day prior to surgical intervention to several days after said intervention. It consists of the preoperative, intraoperative and postoperative period. Patient education Investigation used at surgery Coagulation status (ie. INR <2) Imaging scans for day of surgery Pre-operative care Aims: to provide…

Acute Respiratory Distress Syndrome

Overview ARDS is an acute, diffuse, inflammatory lung injury that leads to increased pulmonary vascular permeability, increased lung weight, and a loss of aerated tissue. Clinical hallmarks of ARDS are hypoxemia and bilateral radiographic opacities, while the pathological hallmark is diffuse alveolar damage. Pathophysiology Aetiology Indirect lung injury: sepsis, shock, trauma, pancreatitis, drug OD, intracranial haemorrhage,…

Inguinal Hernia

Overview Higher incidence among men 40 to 59 years of age. Although there are many different types of hernias, they are usually related to the abdomen, with approximately 75% of all hernias occurring in the inguinal region. Hernia contains omentum (90% of cases) or intestine (10% of cases). Inguinal hernias are at risk of irreducibility or incarceration, which…

Peptic Ulcer Disease

Overview Peptic ulcer refers to an ulcer in the lower oesophagus, stomach or duodenum. Incidence ↑ with age; both sexes are similarly affected. In the developed world, Helicobacter pylori incidence has been slowly ↓ over the past 50 yrs; Non-Steroidal Anti-Inflammatory drug (NSAID) use has ↑. Peptic ulcers remain common worldwide, especially in the developing world where H. pylori infection is prevalent.…

Severe Combined Immunodeficiency (SCID)

Overview Severe combined immunodeficiency (SCID) is the most severe form of primary immunodeficiency, characterised by profound defects in both humoral (B-cell) and cellular (T-cell) immunity. It presents in infancy with recurrent, severe, and opportunistic infections, chronic diarrhoea, and failure to thrive. Without curative therapy, most infants die within the first year of life. Incidence is…

Paediatric Respiratory Distress Syndrome

Overview Respiratory distress syndrome (RDS) also known as hyaline membrane disease is a pulmonary disease resulting from immature lung development and surfactant deficiency. Most frequently seen in preterm infants, the clinical presentation is characterized by signs of respiratory distress including nasal flaring, tachypnea, and grunting (an expiratory sound that is heard as the infant exhales…

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