Antiphospholipid antibodies (aPL) are a group of autoantibodies that target phospholipids and phospholipid-binding proteins, leading to an increased risk of thrombosis and pregnancy complications. Their detection is crucial in diagnosing antiphospholipid syndrome (APS), a condition associated with recurrent venous or arterial thrombosis and obstetric complications such as preeclampsia or fetal loss. Understanding aPL is essential for effective management and prevention of these serious outcomes.