Hirschsprung's disease is a congenital disorder characterised by absence of enteric ganglion cells in the distal colon, causing functional bowel obstruction due to impaired peristalsis. Clinically, it presents with chronic constipation and abdominal distension in neonates or infants, requiring surgical resection of the aganglionic segment. A key complication is enterocolitis, which can be life-threatening if untreated.
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