Wolfram syndrome is a rare genetic disorder characterised by the triad of diabetes insipidus, diabetes mellitus, and optic atrophy, often accompanied by hearing loss and neurological deficits. It is crucial in clinical practice due to its multisystem involvement, necessitating a multidisciplinary approach for management and genetic counselling. A key association is the increased risk of psychiatric disorders, highlighting the need for comprehensive care and monitoring in affected individuals.

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