IL-23 axis

The IL-23 axis refers to the signalling pathway involving interleukin-23 (IL-23), a cytokine that plays a crucial role in the differentiation and maintenance of T helper 17 (Th17) cells, which are important in immune responses. This axis is significant in clinical practice as it is implicated in the pathogenesis of autoimmune diseases such as psoriasis and inflammatory bowel disease, where dysregulation can lead to chronic inflammation and tissue damage. Targeting the IL-23 axis with specific therapies has shown promise in managing these conditions.