Sulphation is a biochemical process involving the addition of a sulphate group to a molecule, typically mediated by sulphotransferase enzymes. This modification is crucial for the metabolism and detoxification of various substances, including drugs and hormones, enhancing their solubility and excretion. Impaired sulphation can lead to drug toxicity or adverse reactions, exemplified by the increased risk of side effects from paracetamol in individuals with compromised sulphation pathways.
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