Vasculopathy refers to any disease or disorder affecting blood vessels, which can lead to impaired blood flow and tissue ischemia. It is clinically significant as it can contribute to various cardiovascular complications, including stroke and myocardial infarction, depending on the vessels involved. A key example is diabetic vasculopathy, where chronic hyperglycaemia damages endothelial cells, increasing the risk of atherosclerosis and peripheral vascular disease.