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Rheumatoid arthritis is a common systemic inflammatory disease characterized by the presence of a destructive polyarthritis with a predisposition for affecting the small joints of the hands and feet and the wrists. Rheumatoid arthritis (RA) is the most common inflammatory arthritis, with a lifetime prevalence of up to 1 percent worldwide. Like many autoimmune diseases, the etiology of RA is multifactorial
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