Glucocorticoid Induced Osteoporosis and Fractures – mechanism and pathophysiology of fractures

Glucocorticoids are used in many inflammatory, autoimmune conditions. While being used to treat an underlying disease gluocorticoids are associated with an appreciable risk of bone loss and increases risk of fracture, which is most pronounced in the first few months of use. In general risk of fracture increases with age, dose and duration of use. Risk of fractures increase with doses as low as 2.5 to 7.5 mg daily.