Large-vessel vasculitis

Large-vessel vasculitis refers to a group of inflammatory disorders that primarily affect the aorta and its major branches, leading to vessel wall thickening, stenosis, or aneurysm formation. It is clinically significant as it can result in severe complications such as ischemia, organ damage, or stroke due to compromised blood flow. An important example is giant cell arteritis, which can cause vision loss if not promptly diagnosed and treated.