Behçet’s disease

Behçet’s disease is a chronic, systemic vasculitis characterised by recurrent oral and genital ulcers, uveitis, and skin lesions. It matters in clinical practice due to its potential to cause significant morbidity, affecting multiple organ systems, including the eyes and joints, which can lead to vision loss or disability. A key association is its prevalence along the Silk Road, with increased incidence in regions such as Turkey and Japan, highlighting its geographical and genetic factors.