Chronic hypokalaemia is a persistent deficiency of potassium in the bloodstream, typically defined as serum potassium levels below 3.5 mmol/L. It is clinically significant as potassium is crucial for maintaining normal cellular function, particularly in cardiac and muscular tissues; low levels can lead to arrhythmias, muscle weakness, and impaired neuromuscular transmission. A common association is the use of diuretics, which can exacerbate potassium loss and contribute to this condition.

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