Fibroblast activation refers to the process by which fibroblasts, the primary cells responsible for extracellular matrix production, become stimulated in response to injury or inflammation. This activation is crucial in wound healing and tissue repair but can lead to excessive fibrosis and scarring if dysregulated. A key association is its role in conditions like pulmonary fibrosis, where abnormal fibroblast activity contributes to lung tissue stiffening and impaired function.
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