Granulomatosis with polyangiitis

Granulomatosis with polyangiitis is a systemic vasculitis characterized by necrotizing granulomatous inflammation affecting small to medium-sized blood vessels, primarily involving the respiratory tract and kidneys. It is crucial in clinical practice due to its potential for rapid progression and severe complications, such as renal failure. A key association is the presence of anti-neutrophil cytoplasmic antibodies (ANCA), particularly myeloperoxidase-ANCA, which aids in diagnosis and monitoring.