Ionotrophy refers to the strength of myocardial contraction, influenced by factors such as calcium availability and adrenergic stimulation. It is clinically significant as it directly affects cardiac output and overall heart function, particularly in conditions like heart failure where impaired contractility is common. A key association is the use of inotropic agents, such as dobutamine, which can enhance contractility but may also lead to increased myocardial oxygen demand and arrhythmias.
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