A negative chronotropic effect refers to a decrease in heart rate due to the influence of certain factors, such as autonomic nervous system activity or pharmacological agents like beta-blockers. This effect is clinically significant as it can help manage conditions like hypertension and arrhythmias by reducing cardiac workload and oxygen demand. An example of a key association is the use of digoxin in heart failure, which can enhance cardiac efficiency while lowering heart rate.
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