A shortened PR interval refers to a duration of less than 120 milliseconds between the onset of atrial depolarisation and the onset of ventricular depolarisation on an electrocardiogram (ECG). This finding is clinically significant as it may indicate conditions such as Wolff-Parkinson-White syndrome, where there is an accessory pathway for conduction, potentially leading to tachyarrhythmias. Prompt recognition is crucial to prevent complications like atrial fibrillation or other arrhythmias.

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