Snuffbox tenderness refers to pain elicited by palpation of the anatomical snuffbox, a triangular depression on the lateral wrist bordered by the tendons of the thumb. It is clinically significant as a sensitive indicator of scaphoid bone injury, which may not be visible on initial X-rays but requires prompt diagnosis to prevent complications. A key concern is that untreated scaphoid fractures can lead to avascular necrosis and chronic wrist dysfunction.