Tracheal cytotoxin is a peptidoglycan fragment produced by Bordetella pertussis that damages ciliated epithelial cells in the respiratory tract, leading to impaired mucociliary clearance. This toxin is clinically significant as it contributes to the pathogenesis of whooping cough, resulting in severe coughing fits and potential complications such as pneumonia. Understanding its role aids in developing targeted therapies and preventive measures against respiratory infections.
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