ZnT8, or zinc transporter 8, is a protein encoded by the SLC30A8 gene, primarily expressed in pancreatic beta cells, where it plays a crucial role in insulin secretion by regulating zinc levels. Its significance lies in its association with type 2 diabetes, as genetic variants of ZnT8 are linked to an increased risk of the disease, making it a potential biomarker for susceptibility and a target for therapeutic interventions. Autoantibodies against ZnT8 can also indicate autoimmune diabetes.
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