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Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder that affects the connection between nerve cells and muscle cells (neuromuscular junction). It is characterized by weakness and fatigue of the muscles, particularly those in the legs, pelvis, and torso.
LEMS is caused by antibodies that attack and destroy the receptors that allow nerve cells to communicate with muscle cells. This leads to a decrease in the transmission of nerve impulses to the muscles, causing weakness and fatigue.
Symptoms of LEMS may include muscle weakness and fatigue, difficulty climbing stairs or standing up from a seated position, and a decreased ability to sweat. The condition can also cause symptoms that affect the respiratory system, such as shortness of breath and difficulty swallowing.
LEMS is typically diagnosed based on a combination of physical examination, nerve conduction studies, and imaging tests. Treatment may involve the use of medications to improve muscle function and reduce inflammation, as well as rehabilitation and physical therapy to help improve muscle strength and function.
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