Nephrotoxic drugs are medications that can cause damage to the kidneys, leading to impaired renal function or acute kidney injury. Understanding nephrotoxicity is crucial in clinical practice, as it informs drug selection, dosing, and monitoring, particularly in patients with pre-existing renal conditions. A key example of a nephrotoxic drug is aminoglycosides, which can lead to tubular injury and subsequent electrolyte imbalances if not carefully managed.

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