Overview Peptic ulcer refers to an ulcer in the lower oesophagus, stomach or duodenum. Incidence ↑ with age; both sexes are similarly affected. In the developed world, Helicobacter pylori incidence has been…

Overview Acute pancreatitis is a relatively common condition presenting with severe, acute, constant epigastric pain. Incidence of ~5 per 100,000/year. Acute pancreatitis has a significant mortality.…

Overview Acute kidney injury (AKI) (formerly acute renal failure) is the syndrome arising from a rapid fall in GFR (over hours to days). It is characterized by retention of both nitrogenous (including Urea…

Overview Guillain-Barré Syndrome (GBS) is an acute, immune-mediated polyneuropathy typically triggered by a preceding gastrointestinal or respiratory infection. It is characterised by an autoimmune attack on…

Overview Third most common cause of death worldwide and most common cause of neurological disability. It is subdivided into ischaemic stroke (caused by vascular occlusion or stenosis) and haemorrhagic stroke…

Overview Cardiac arrest is a state of circulatory failure due to a loss of cardiac systolic function. It is the result of 4 specific cardiac rhythm disturbances: Epidemiology Initial Assessment and…

Overview Pulmonary embolism occurs most often from a dislodged thrombus from the lower limb (DVT). The embolus travels towards the lung and becomes lodged in the pulmonary artery resulting in infarction of…

Overview ARDS is an acute, diffuse, inflammatory lung injury that leads to increased pulmonary vascular permeability, increased lung weight, and a loss of aerated tissue. Clinical hallmarks of ARDS are…

Overview Sjögren’s Syndrome is a chronic, systemic autoimmune disorder characterized by lymphocytic infiltration and destruction of exocrine glands, primarily affecting the salivary and lacrimal glands, leading…

Overview Deep vein thrombosis (DVT) is the formation of a blood clot in a vein deep under the skin 25-50% of surgical patients and many non-surgical patients. 65% of DVT are below the knee are symptomatic and…