Scleroderma is a chronic autoimmune connective tissue disorder characterized by skin thickening and fibrosis, often affecting internal organs. It matters clinically due to its potential to cause significant morbidity through complications such as pulmonary hypertension, renal crisis, and gastrointestinal dysfunction. One key association is the presence of specific autoantibodies, such as anti-Scl-70, which can aid in diagnosis and prognosis.