Innate immunity

Innate immunity is the body's first line of defence against pathogens, comprising physical barriers (like skin), immune cells (such as macrophages and neutrophils), and soluble factors (like cytokines) that respond rapidly to infections. It is crucial in clinical practice as it provides immediate protection and influences the adaptive immune response. An example of its significance is the role of innate immunity in sepsis, where its dysregulation can lead to severe systemic inflammation and organ failure.