Primary sclerosing cholangitis

Primary sclerosing cholangitis is a chronic, progressive liver disease characterized by inflammation and fibrosis of the bile ducts, leading to bile duct strictures and cholestasis. It is clinically significant due to its association with inflammatory bowel disease and the increased risk of cholangiocarcinoma. Early recognition and management are crucial, as patients may require liver transplantation as the disease advances, significantly impacting their prognosis and quality of life.