Reed-Sternberg cells are large, abnormal B lymphocytes typically found in Hodgkin lymphoma, characterised by their distinctive bi- or multinucleated appearance. Their presence is crucial for diagnosing Hodgkin lymphoma, as they indicate the disease's specific pathology and help differentiate it from non-Hodgkin lymphomas. A key association is the increased risk of secondary malignancies in patients treated for Hodgkin lymphoma, underscoring the importance of long-term follow-up.
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