Lymphoma

Types of Lymphoma

Lymphoma is malignancy originating in the lymph nodes. There are two types:

• Hodgkins lymphoma
• Non-hodgkins lymphoma

Classic Clinical Presentation 

• Lymphadenopathy
• Constitutional symptoms
  • Fever
  • Night sweats
  • Weight loss

Differential Diagnosis of Lymphadenopathy

• Lymphoma
• Leukaemia
• Metastasis
• Infection
• Connective tissue disease – rheumatoid arthritis, SLE
• Infiltration – sarcoidosis
• Drugs – phenytoin

	Hodgkin’s lymphoma	Non-Hodgkin’s lymphoma
	Bimodal Distribution
Risk Factors	EBV	EBV may be associated with HIV
Lymph Nodes	Contiguous and localized	Noncontiguous and peripheral
Histology	Reed-Sternberg cells	Majority involve B cells
Treatment	ABVD	R-CHOP