Lymphoma is malignancy originating the lymph nodes. There are two types:

Classic Clinical Presentation 

  • Lymphadenopathy
  • Constitutional symptoms
    • Fever
    • Night sweats
    • Weight loss

Differential Diagnosis of Lymphadenopathy

  • Lymphoma
  • Leukaemia
  • Metastasis
  • Infection
  • Connective tissue disease - rheumatoid arthritis, SLE
  • Infiltration - sarcoidosis
  • Drugs - phenytoin
Hodgkin's lymphoma Non-Hodgkin's lymphoma
Bimodal Distribution
Risk Factors EBV EBV may be associated with HIV
Lymph Nodes Contiguous and localized Noncontiguous and peripheral
Histology Reed-Sternberg cells Majority involve B cells
Treatment ABVD R-CHOP