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Kawasaki Disease

Overview Kawasaki disease is an acute systemic vasculitis affecting small and medium-sized vessels predominantly affecting children under 5 years old. It is the leading cause of acquired heart disease in children in developed countries. Kawasaki is often self-limiting, but 20–25% risk of coronary artery aneurysms if untreated 1 . Vasculitis : Inflammation of blood vessel…

Asthma (Adults)

Clinical features of asthma such as dyspnoea, chest tightness and wheezing can mimic other respiratory conditions. It is important to take a careful history and examination and ideally demonstrate reversible airflow obstruction. Other clinical features of asthma arise during periods of bronchoconstriction (ie. exercise, smoking, stress, cold air). Exacerbation of asthma confounds the breathing difficulty, cough and wheeze in patients.

Vasculitides

Classification Large-vessel vasculitis Takayasu arteritis Medium-sized vessel vasculitis Childhood polyarteritis nodosa Kawasaki Disease Small-vessel vasculitis Granulomatosis with polyangiitis (Wegener’s Syndrome) Eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome) Henoch-Schönlein purpura (Spring Fever) Other vasculitides Behçet’s disease Kawasaki disease and HSP are the most common childhood vasculitis followed by PAN.

Cerebral Palsy

Overview Cerebral palsy is a non-Progressive neurological disorder. Usually with significant motor component. Clinical presentation overtime changes due to increased developmental challenges.Cerebral palsy (CP) is the most common physical disability in childhood. Prevalence is about 1 – 3/ 1000 live births. Cerebral palsy can affect: Cerebral cortex – causing spasticity Basal ganglia – causing dyskinesia…

Henoch–Schönlein Purpura (IgA Vasculitis)

Overview Henoch–Schönlein purpura (HSP), now termed IgA vasculitis, is the most common systemic vasculitis in children, characterised by IgA1-dominant immune complex deposition in small vessels, particularly affecting the skin, joints, gastrointestinal tract, and kidneys. It predominantly occurs in children aged 3–10 years, with a slight male predominance, and often follows an upper respiratory tract infection.…

Acute Respiratory Distress Syndrome

Overview ARDS is an acute, diffuse, inflammatory lung injury that leads to increased pulmonary vascular permeability, increased lung weight, and a loss of aerated tissue. Clinical hallmarks of ARDS are hypoxemia and bilateral radiographic opacities, while the pathological hallmark is diffuse alveolar damage. Pathophysiology Aetiology Indirect lung injury: sepsis, shock, trauma, pancreatitis, drug OD, intracranial haemorrhage,…

Congenital Heart Defect

Overview Congenital heart disease (CHD) is the most common congenital disorder in newborns. Classification Acyanotic and Cyanotic Pulmonary blood flow Increased Decreased Normal Cyanotic (T's) Acynotic (D's) T etralogy of Fallot AS D T ransposition of the great vessles VS D T ricuspid atresia AVS D T runcus arteriosus Patent D uctus Arteriosus   Other:…

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