Medical science, drawn into focus.

Takayasu Arteritis 

Overview Takayasu arteritis is a rare, chronic large-vessel vasculitis primarily affecting the aorta and its major branches, leading to stenosis, occlusion, or aneurysm formation. It most commonly affects young women (<40 years), particularly of Asian descent. The global incidence is estimated at 1–2 per million per year, with a female predominance (F:M ~9:1). It is…

Hodgkins Lymphoma

Overview Hodgkin lymphoma (HL) arises from germinal center or post-germinal center B cells. HL has a unique cellular composition, containing a minority of neoplastic cells ( Reed-Sternberg cells  and their variants) in an inflammatory background. Reed-Sternberg cell is a characteristic feature of HL. Epidemiology Lymphoma is divided into Hodgkins and Non-Hodgkins Hodgkins lymphoma accounts for…

Eosinophilic Granulomatosis with Polyangiitis

Overview EGPA (formerly Churg-Strauss syndrome) is a rare, small-to-medium vessel necrotizing vasculitis characterized by asthma, eosinophilia, and extravascular granulomas. It commonly affects the lungs, skin, peripheral nerves, and heart. Annual incidence: ~1–3 per million; peak onset in 40s–60s; no significant gender bias. Strongly associated with MPO-ANCA positivity in ~40–60% of patients; others are ANCA-negative. Eosinophilia…

Pelvic Inflammatory Disease

Overview Pelvic inflammatory disease (PID) comprises a spectrum of inflammatory disorders of the upper female genital tract, including any combination of endometritis, salpingitis, tubo-ovarian abscess, and pelvic peritonitis. Causative organisms are either sexually transmitted (such as C trachomatis , N gonorrhoeae , Mycoplasma genitalium ) or endogenous vaginal organisms (for example, Bacteroides species) that ascend…

Anklylosing Spondylitis (AS)

Overview Ankylosing spondylitis (AS) is a chronic, progressive inflammatory arthritis that primarily affects the axial skeleton, especially the sacroiliac joints and spine. It is a subtype of the seronegative spondyloarthropathies and is characterised by inflammatory back pain, morning stiffness, and eventual spinal fusion in severe cases. AS often presents in young adults, typically males, and…

Leukaemia

Overview  Leukemia is a common malignancy in children and adults that occurs when alterations in normal cell regulatory processes cause uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Leukaemia:  Clonal proliferation of hematopoietic stem cells in the bone marrow Acute Leukaemia:  Clonal proliferation of hematopoietic stem cells in the bone marrow that develops…

Anal Abscess

Overview Anorectal abscess is an infection of soft tissue around the anus. It causes severe perianal pain and swelling. 30% to 70% of anorectal abscesses are associated with an anorectal fistula. It is two times more likely to present in males. 1 2 Anal Abscess Anorectal abscess: collection of pus in anorectal spaces resulting from…

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