Medical science, drawn into focus.

Thyroiditis

Overview Thyroiditis: Varied group of disorder all characterized by some form of thyroid inflammation Hyperthyroidism:  denote conditions in which hyperfunction of the thyroid leads to thyrotoxicosis. Hypothyroidism:  Variety of abnormalities that cause insufficient secretion of thyroid hormones. The most common cause is autoimmune thyroid disease Thyrotoxicosis:  denotes the clinical, physiological, and biochemical findings that result…

Neural Tube Defect

Overview Neural tube defects (NTDs) are a group of major congenital anomalies comprising anencephaly, spina bifida and encephalocele that result from very early disruption in the development of the brain and spinal cord. These conditions are often incompatible with life. Survivors frequently require intensive, costly, lifelong health and social care. Neural tube defect (NTD): Severe…

Goodpasture Syndrome (Anti-GBM disease)

Overview Goodpasture syndrome, now more precisely termed anti-glomerular basement membrane (anti-GBM) disease , is a rare autoimmune small-vessel vasculitis affecting lungs and kidneys, typically manifesting with diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis.  Microscopic polyangiitis (MPA) has an estimated incidence of approximately 0.5 to 1.8 cases per million per year. It demonstrates a bimodal age…

Acute Liver (Hepatic) Failure

Overview Acute liver failure is a rare but life-threatening critical illness that occurs most often in patients who do not have preexisting liver disease. Acute liver failure is seen most commonly in previously healthy adults in their 30s and presents unique challenges in clinical management. The clinical presentation usually includes hepatic dysfunction, abnormal liver biochemical…

X-linked Agammaglobulinaemia (XLA / Bruton’s Disease)

Overview X-linked agammaglobulinaemia (XLA) is a rare primary immunodeficiency caused by mutations in the Bruton’s tyrosine kinase (BTK) gene , leading to failure of B-cell maturation. It results in profound hypogammaglobulinaemia and susceptibility to recurrent bacterial infections, particularly with encapsulated organisms. It usually presents after 6 months of age (once maternal IgG wanes). Prevalence is…

Hydatidiform Mole (Molar Pregnancy)

Overview Hydatidiform moles are part of a group of diseases falling under gestational trophoblastic disease. A hydatidiform mole refers to the abnormal growth of trophoblastic cells in the placenta, resulting in edematous placental villi that form hydatidiform structures. It is classified as either partial or complete, causing either abnormal foetal development (resulting in foetal demise)…

Atopic Dermatitis (Eczema)

Overview Atopic dermatitis is a chronic highly pruritic (itchy) inflammatory skin disease. Atopic dermatitis and eczema are often used synonymously. Atopic dermatitis primarily affect young children and is often associated with other atopic disorders, such as allergic rhinitis and asthma. The prevalence of atopic dermatitis has doubled or tripled in industrialised countries during the past three decades.…

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