Medical science, drawn into focus.

Psoriasis

Overview Psoriasis is a chronic, immune-mediated, inflammatory skin disease with systemic associations, characterized by sharply demarcated erythematous plaques with overlying scale, most commonly plaque psoriasis. [1-4] It affects about 1% to 3% of the global population, although prevalence varies by geography and ethnicity, and plaque psoriasis accounts for about 80% to 90% of cases. [1,2]…

Acute Respiratory Distress Syndrome

Overview ARDS is an acute, diffuse, inflammatory lung injury that leads to increased pulmonary vascular permeability, increased lung weight, and a loss of aerated tissue. Clinical hallmarks of ARDS are hypoxemia and bilateral radiographic opacities, while the pathological hallmark is diffuse alveolar damage. Pathophysiology Aetiology Indirect lung injury: sepsis, shock, trauma, pancreatitis, drug OD, intracranial haemorrhage,…

Obesity

Overview Overweight and obesity are common worldwide and are associated with many conditions, particularly diabetes, hypertension and dyslipidemia. Overweight and obesity are defined as a moral or excessive fat accusation that presents a risk to health Obesity is now dramatically on the rise in low and middle-income countries. Management should include diet, physical activity, and…

Mixed Connective Tissue Disease (MCTD) 

Overview MCTD is a systemic autoimmune rheumatic disease characterized by overlapping clinical features of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), polymyositis, with rheumatoid arthritis with high titres of anti-U1 RNP antibodies. It typically affects women aged 20–40 years. Prevalence is estimated at 3.8 per 100,000; more common in females (F:M ~9:1). The disease course…

Acute Appendicitis

Overview Acute appendicitis is an acute inflammation of the vermiform (worm-like) appendix. It is mainly caused by obstruction of the lumen of the appendix by stool, infective agents or lymphoid hyperplasia. Acute appendicits is the most common abdominal surgical emergency in the world, with a lifetime risk of 6.9% in females and 8.6% in males.…

Peripheral Arterial Disease (Chronic Lower Limb Ischaemia)

 Overview Ankle-Brachial Index (ABI): Ratio of ankle to brachial systolic blood pressure, determined using Doppler ultrasound flow. Claudication: Pain, ache, or cramp in muscles that increases with walking or leg exertion in a predictable manner and resolves with rest. Peripheral arterial disease: Atherosclerosis leading to narrowing of the major arteries distal to the aortic arch.…

Anorexia Nervosa

“ To lose confidence in one’s body is to lose confidence in oneself .” ― Simone de Beauvoir " Every woman knows that, regardless of all her other achievements, she is a failure if she is not beautiful ." – Germaine Greer Overview Eating disorders have traditionally been classified into two well-established categories. They are…

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