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Guillain–Barré Syndrome

Overview Guillain-Barré Syndrome (GBS) is an acute, immune-mediated polyneuropathy typically triggered by a preceding gastrointestinal or respiratory infection. It is characterised by an autoimmune attack on the peripheral nerves, leading to mainly demyelination but also axonal degeneration, which impairs nerve conduction and causes muscle weakness and paralysis. GBS affects about 1–2 per 100,000 people annually.…

Parkinson's Disease

Overview Parkinson’s disease is a progressive neurodegenerative disorder characterised by tremor, rigidity, bradykinesia, and a wide spectrum of non-motor symptoms including sleep disorders, hyposmia, bladder and bowel dysfunction, fatigue, dementia, and other neuropsychiatric symptom. Although the disease has no cure, available treatments effectively control motor symptoms and improve quality of life. Parkinson disease affects approximately 1…

Pelvic Inflammatory Disease

Overview Pelvic inflammatory disease (PID) comprises a spectrum of inflammatory disorders of the upper female genital tract, including any combination of endometritis, salpingitis, tubo-ovarian abscess, and pelvic peritonitis. Causative organisms are either sexually transmitted (such as C trachomatis , N gonorrhoeae , Mycoplasma genitalium ) or endogenous vaginal organisms (for example, Bacteroides species) that ascend…

Myelofibrosis

Overview Myelofibrosis is a type of myeloproliferative diseasecharacterized by clonal myeloid expansion, followed by progressive fibrous connective tissue deposition in the bone marrow, resulting in bone marrow failure. Clonal evolution can also occur, with an increased risk of transformation to acute myeloid leukemia. In addition, disabling constitutional symptoms secondary to the high circulating levels of…

Behçet’s Disease

Overview Behçet’s syndrome is a chronic, relapsing, multisystem inflammatory disorder and variable-vessel vasculitis characterized classically by recurrent oral ulcers, genital ulcers, ocular inflammation, and skin lesions. It can also involve the joints, vessels, nervous system, and gastrointestinal tract.  The disease is most prevalent along the historic “Silk Road” region, including Turkey, the Middle East, and…

Scarlatina (Scarlet Fever)

Hyperlipidaemia

Overview Hyperlipidaemia is an umbrella term which encompasses genetic and acquired disorders that raise lipid levels within the blood. Hyperlipidaemia does not independently cause clinical symptoms, rather can lead to other disorders that can manifest in possible life-threatening presentations. Most notably, hyperlipidaemia causes atherosclerosis which may lead to cardiovascular, cerebrovascular, and peripheral vascular disease. 1…

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