Sulfasalazine is a sulfonamide antibiotic and anti-inflammatory medication primarily used to treat inflammatory bowel disease, such as ulcerative colitis, and rheumatoid arthritis. Its clinical significance lies in its ability to reduce inflammation and maintain remission in these chronic conditions, improving patients' quality of life. A key association is its potential to cause adverse effects like hypersensitivity reactions, which can lead to skin rashes or liver dysfunction.

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