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Archives: Diseases

Pertussis

AuthorMegan MinerArmando Faigl Overview Pertussis, also known as “whooping cough”, is a contagious, acute respiratory infection caused by the bacterium Bordetella pertussis. In babies, the infection can sometimes lead to…
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Chagas Disease

AuthorsMegan Miner Armando Faigl  Overview Chagas disease is caused by the parasitic protozoan Trypanosoma cruzi (T. cruzi) and is potentially life-threatening. These parasites often live within triatomine bugs. Following a bite…
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Myasthenia Gravis

Overview Myasthenia Gravis (MG) is a chronic autoimmune neuromuscular disorder where antibodies target acetylcholine receptors (AChR) or MuSK proteins at the post-synaptic membrane, impairing neuromuscular transmission and causing muscle weakness…
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Guillain–Barré Syndrome

Overview Guillain-Barré Syndrome (GBS) is an acute, immune-mediated polyneuropathy typically triggered by a preceding gastrointestinal or respiratory infection. It is characterised by an autoimmune attack on the peripheral nerves, leading…
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Diabetes Mellitus type I

Overview Type 1 diabetes is B-cell destruction leading to absolute insulin deficiency. It accounts for 5-10% of all diabetes. Type I diabetes is divided into two types: Immune mediated and…
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Myotonic Dystrophy

Overview Autosomal dominant disease characterised by trinucleotide repeat of CTG. Also known as Dystrophica Myotoncia the disease is causes an increase in muscle tone (Myotonia) with associated degeneration and shrinkage…
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Paracetamol Overdose

Overview Paracetamol overdose is a common cause of hospital presentation. Paracetamol is an analgesic and antipyretic drug used in both children and adults. Its mechanism of action is yet to…
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Digoxin Toxicity

75 year old presents to emergency with a 2 day history nausea, vomiting, abdominal pain and diarrhoea. He has not been tolerating oral fluids and is currently confused with a…
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Osgood Schlatter

Overview In this common disorder of adolescence the tibial tubercle becomes painful and ‘swollen’. Although often called osteochondritis and apophysitis, it is nothing more than a traction injury of the…
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Paediatric Bacterial Cutaneous Infection

Meningitis 5 year old presents with non-blanching rash, fever, headache, photophobia and neck stiffness. Aetiology Clinical presentation Investigations Treatment Complications Pertussis 8 month old presents with paroxysmal cough and fever.…
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