Liver failure is a clinical syndrome characterised by the liver's inability to perform its essential functions, leading to a range of metabolic disturbances and systemic complications. It is crucial in clinical practice as it can result in life-threatening conditions such as coagulopathy, hepatic encephalopathy, and multi-organ failure, necessitating urgent intervention. A key association is acute liver failure due to viral hepatitis, which can rapidly progress and require liver transplantation.