Proton pump inhibitors

Proton pump inhibitors (PPIs) are a class of medications that irreversibly inhibit the H+/K+ ATPase enzyme in the gastric parietal cells, leading to decreased gastric acid secretion. They are crucial in managing conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers, as they promote healing and symptom relief. However, long-term use of PPIs is associated with potential complications, including an increased risk of Clostridium difficile infection and osteoporosis-related fractures.