Medical science, drawn into focus.

Testicular Torsion

Overview Testicular torsion is a urological emergency caused by twisting of the spermatic cord, leading to acute interruption of blood flow to the testis and rapid ischemia. It most commonly occurs in adolescents (peak 12–18 years) but can occur at any age, including neonates. The incidence is approximately 1 in 4,000 males under 25 years. Early…

Chronic Granulomatous Disease 

Overview Chronic granulomatous disease (CGD) is a rare, inherited primary immunodeficiency characterised by defective function of the NADPH oxidase enzyme complex in phagocytes, leading to failure of the oxidative burst required for intracellular killing of pathogens. This results in recurrent, often life-threatening bacterial and fungal infections, particularly with catalase-positive organisms, and predisposes to granuloma formation…

Myelofibrosis

Overview Myelofibrosis is a type of myeloproliferative diseasecharacterized by clonal myeloid expansion, followed by progressive fibrous connective tissue deposition in the bone marrow, resulting in bone marrow failure. Clonal evolution can also occur, with an increased risk of transformation to acute myeloid leukemia. In addition, disabling constitutional symptoms secondary to the high circulating levels of…

Behçet’s Disease

Overview Behçet’s syndrome is a chronic, relapsing, multisystem inflammatory disorder and variable-vessel vasculitis characterized classically by recurrent oral ulcers, genital ulcers, ocular inflammation, and skin lesions. It can also involve the joints, vessels, nervous system, and gastrointestinal tract.  The disease is most prevalent along the historic “Silk Road” region, including Turkey, the Middle East, and…

ACL Tear

Overview Anterior cruciate ligament (ACL) tear is one of the most common knee injuries, particularly in young athletes involved in pivoting sports (soccer, basketball, skiing). ACL injuries account for ~50% of all knee ligament injuries, with an incidence of ~68 per 100,000 annually, more common in females due to anatomical and biomechanical risk factors. ACL…

Complex Regional Pain Syndrome (CRPS) 

Overview CRPS is a disproportionate, regional pain syndrome of a limb that typically follows injury or surgery and features sensory, vasomotor, sudomotor/oedema, and motor/trophic changes. The prevalence after limb fracture/surgery varies widely (≈1–7% overall, higher in some distal radius cohorts) and early recognition with rehabilitation improves outcome. Important risk factors include fracture (especially wrist/ankle), immobilisation,…

Irritable Bowel Syndrome (IBS)

Overview Complex chronic syndrome characterised by recurrent abdominal pain and bowel dysfunction, in the absence of a structural abnormality. It is not associated with an increase in mortality, however, it is associated with substantial morbidity and a significant decrease in an individual’s quality of life. IBS IBD IBS belongs to a group of disorders collectively known as Functional…

Full resource library