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Vitamin B12 Deficiency Anaemia

Overview Vitamin B 12 (cobalamin) deficiency is a common cause of megaloblastic anemia, a variety of neuropsychiatric symptoms, and elevated serum homocysteine levels, especially in older persons. The recognition and treatment of vitamin B 12 deficiency is critical since it is a reversible cause of bone marrow failure and demyelinating nervous system disease. Anaemia (Anemia):  The…

VEXAS Syndrome

Overview VEXAS syndrome is a late-onset, adult autoinflammatory disease caused by acquired somatic mutations in the UBA1 gene, leading to dysregulated innate immunity, systemic inflammation, and overlapping haematologic and rheumatologic manifestations.  VEXAS stands for Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic. It predominantly affects older males due to its X-linked nature and typically presents with refractory…

Undifferentiated Connective Tissue Disease (UCTD)

Overview UCTD is a systemic autoimmune disease with features of connective tissue disease (CTD), but does not fulfill classification criteria for any specific CTD such as SLE, Sjögren’s syndrome, systemic sclerosis, or polymyositis. It is a diagnosis of exclusion used for patients with persistent autoimmune features who do not evolve into a defined CTD. Commonly…

Meniscal Tear

Overview Medial and lateral knee joint menisci serve to transfer load and absorb shock, aid joint stability and provide lubrication. The meniscus is the most commonly injured structure in the knee joint. Acute tears occurs after axial loading combined with rotation. People may complain of a sensation of clicking or catching of the knee with…

Septic Arthritis

Overview Septic arthritis refers to infection in a joint; it is usually caused by bacteria but can be caused by fungi or mycobacteria. Septic arthritis due to bacterial infection is often a destructive form of acute arthritis. Arthritis: Inflammation of joint Arthrosis: Degeneration of joint Septic Arthritis: Infection of joint Pathophysiology Septic arthritis involves bacterial…

Takayasu Arteritis 

Overview Takayasu arteritis is a rare, chronic large-vessel vasculitis primarily affecting the aorta and its major branches, leading to stenosis, occlusion, or aneurysm formation. It most commonly affects young women (<40 years), particularly of Asian descent. The global incidence is estimated at 1–2 per million per year, with a female predominance (F:M ~9:1). It is…

Myelofibrosis

Overview Myelofibrosis is a type of myeloproliferative diseasecharacterized by clonal myeloid expansion, followed by progressive fibrous connective tissue deposition in the bone marrow, resulting in bone marrow failure. Clonal evolution can also occur, with an increased risk of transformation to acute myeloid leukemia. In addition, disabling constitutional symptoms secondary to the high circulating levels of…

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