Overview Complement deficiencies are rare primary immunodeficiencies resulting from inherited absence or dysfunction of complement proteins, regulators, or receptors. They predispose to recurrent…

Overview Common Variable Immunodeficiency (CVID) is the most frequent clinically significant primary antibody deficiency, characterised by hypogammaglobulinaemia and impaired antibody responses. It…

Overview Chronic widespread pain (CWP) is a nociplastic pain phenotype defined by persistent (≥3 months) pain affecting multiple body regions, with high comorbidity with fatigue, sleep disturbance, mood symptoms…

Overview Chronic upper limb ischaemia is a form of peripheral arterial disease that results in a symptomatic reduced blood supply to the upper limb. The common symptoms are weakness, cramps, pain, and…

Overview Chronic lower limb ischemia can be classified using the Fontaine classification: Grades III and IV are classified as Critical Limb Ischemia. Intermittent claudication is a type of chronic lower…

Overview Caplan syndrome, also known as rheumatoid pneumoconiosis, is a rare condition seen in patients with rheumatoid arthritis (RA) who have had occupational exposure to inhaled dust, particularly coal dust…

Overview Bowel obstruction is a blockage of intestinal contents, either mechanical (e.g., adhesions, hernias, malignancy) or functional (e.g., ileus), leading to impaired transit, proximal dilation, and…

Overview Atopic dermatitis affects approximately 5 to 20 percent of children worldwideThe incidence of atopic dermatitis appears to be increasing. It may occur in any race or geographic location, although…

Overview Cardiac Valves The heart has 4 valves: The Mitral and tricuspid valves are atrioventricular valves meaning they allow blood to move from the atrium to the ventricles of the heart. This occurs…