Overview Pulmonary embolism occurs most often from a dislodged thrombus from the lower limb (DVT). The embolus travels towards the lung and becomes lodged in the pulmonary artery resulting in infarction of…

Portal Hypertension Overview  Normal portal vein pressure is 5–10mmHg. Portal hypertension develops when the portal pressure is greater than 12mmHg. Mechanism of disease Portal Vein Anatomy CAUSES OF PORTAL…

Overview Paracetamol overdose is a common cause of hospital presentation. Paracetamol is an analgesic and antipyretic drug used in both children and adults. Its mechanism of action is yet to be fully…

Overview Hypermobility Spectrum Disorder (HSD) describes symptomatic joint hypermobility with musculoskeletal (and sometimes systemic) consequences in people who do not meet the 2017 diagnostic criteria…

Author  Overview Collection of pus forming a mass in the liver as a result of infection. Mainly divided into two types Route of infection Pyogenic Liver Abscess  Can be solitary or multiple pus filled masses…

Overview Osteonecrosis of the hip, usually referring to osteonecrosis of the femoral head (ONFH), is a progressive disorder caused by compromised subchondral blood supply leading to death of osteocytes and…

Overview Amyloidosis is a disorder in which misfolded proteins aggregate into insoluble beta-pleated sheet fibrils and deposit extracellularly in tissues, leading to progressive organ dysfunction. It may…

Overview UCTD is a systemic autoimmune disease with features of connective tissue disease (CTD), but does not fulfill classification criteria for any specific CTD such as SLE, Sjögren’s syndrome, systemic…

Overview Seizures are a common occurrence in children. 8% will have at least one seizure by 15 years of age. A seizure is the result of an abnormal paroxysmal discharge by cerebral neurons. Many underlying…

Overview Enteropathic arthritis is a subtype of spondyloarthropathy associated with inflammatory bowel disease (IBD), particularly Crohn’s disease and ulcerative colitis. It affects up to 20% of IBD patients,…