Summary of Mitral Regurgitation MRis leakage of blood backwards through the mitral valve each time the left ventricle contracts. Common causes include mitral prolapse and rheumatic heart disease. The murmur heard in MR is a flat continuous systolic murmur that may radiate to the axilla. Echocardiogram is diagnostic and is important in monitoring. Treatment includes a valve repair/ replacement and annuloplasty.