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Archives: Diseases

Cervical Cancer

Overview Cervical cancer is an HPV-related malignancy of the uterine cervical mucosa. Most cervical tumours contain HPV DNA (99.7%) . There are many variants of HPV, HPV-16 and 18 are the…
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Hyperparathyroidism

This section will mainly focus on Primary Parathyroidism Overview Primary Hyperparathyroidism (PHPT) is generalised disorder calcium, phosphate and bone metabolism due to increased secretion of parathyroid hormone normally leading to…
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Thyroiditis

Overview The term thyroiditis refers to a varied group of disorders all characterized by some form of thyroid inflammation. It includes conditions characterized by thyroid pain and tenderness and those…
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Goitre and Nodules

Overview Goitre refers to an enlarged thyroid gland. Thyroid nodules are common in the general population, especially in women. Goitre results from follicular cell hyperplasia at one or multiple sites…
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Primary Hypothyroidism

Overview Hypothyroidism is a clinical state resulting from underproduction of the thyroid hormones T4 and T3. Most cases (95%) are due to primary hypothyroidism, a failure of the thyroid gland to…
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Hyperthyroidism (Thyrotoxicosis)

Overview The most common cause of hyperthyroidism are Graves disease, multinodular goitre, an autonomously functioning thyroid nodule  (adenoma) and subacute thyroiditis. Graves Disease is more common in women. Multinodular goitre…
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Long-Term Complications of Diabetes (Overview)

Classification Diabetic Retinopathy Overview Diabetes is the most common cause of blindness in the working population. Blindness is preventable. Annual retinal screening is advised for patients at risk. Pre-symptomatic screening…
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Glomerulonephritis

Overview Glomerulonephritis is inflammation of the glomerulus.  Glomerulonephritis is classified by clinical syndrome/presentation (e.g. nephritic or nephrotic syndrome), histological appearance , or by aetiology. We will divide glomerulonephritis broadly into …
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Birth Defects

Overview Birth defects are the leading cause of perinatal and post- neonatal deaths, and result in substantial morbidity and disability in developed countries. There is a wide variety of mechanisms including…
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Polycystic Kidney Disease

Overview The polycystic kidney diseases are among the most common life-threatening inherited diseases worldwide and frequently cause kidney failure. Autosomal dominant polycystic kidney disease (ADPKD) is seen predominantly in adults,…
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