Overview Chronic upper limb ischaemia is a form of peripheral arterial disease that results in a symptomatic reduced blood supply to the upper limb. The common symptoms are weakness, cramps, pain, and…

Overview Nephritic syndrome is one of two clinical patterns seen in glomerular disease. Nephritic Syndrome is characterised by haematuria, proteinuria, hypertension and oligouria. Nephritic syndrome can…

Overview Glomerulonephritis is inflammation of the glomerulus.  Glomerulonephritis is classified by clinical syndrome/presentation (e.g. nephritic or nephrotic syndrome), histological appearance , or…

Overview Hydatidiform moles are part of a group of diseases falling under gestational trophoblastic disease. A hydatidiform mole refers to the abnormal growth of trophoblastic cells in the placenta, resulting…

Overview Graves’ disease is the most common cause of hyperthyroidism, caused by an autoimmune reaction in which TSH receptor autoantibodies stimulate the thyroid gland, leading to an increase in the production…

Overview Osteomalacia (adults) and rickets (children) are disorders of impaired bone mineralisation leading to soft, poorly mineralised bone. It arises when there is insufficient calcium–phosphate supply to the…

Overview Reactive arthritis is a seronegative spondyloarthropathy that occurs after a genitourinary or gastrointestinal infection, typically presenting as an asymmetric oligoarthritis, often with…

Overview Psoriatic arthritis (PsA) is a chronic, immune-mediated inflammatory arthritis associated with psoriasis, affecting up to 30% of patients with skin psoriasis. It commonly presents in adults aged 30–50…

Overview Enteropathic arthritis is a subtype of spondyloarthropathy associated with inflammatory bowel disease (IBD), particularly Crohn’s disease and ulcerative colitis. It affects up to 20% of IBD patients,…