Medical science, drawn into focus.

Granulomatosis with Polyangiitis 

Overview Granulomatosis with polyangiitis (formerly Wegener’s granulomatosis) is a rare, chronic, systemic necrotising vasculitis affecting small-to-medium-sized vessels, characterised by granulomatous inflammation, necrotising vasculitis, and tissue destruction, primarily involving the upper and lower respiratory tracts and kidneys. It falls under the ANCA-associated vasculitides (AAV). Peak incidence is in the 5th–6th decade, with slight male predominance and…

Liver Abscess

Author  Areej Zeeshan Ahmed Dr. Armando Faigl (editor) Overview Collection of pus forming a mass in the liver as a result of infection. Mainly divided into two types Pyogenic Amoebic Route of infection Biliary tract (most common) Gallstones Cholangitis Congenital anomaly causing to bile stasis Portal Vein Peritonitis Hepatic artery Trauma Penetrating Non-penetrating can cause…

Mesenteric Ischaemia

Aetiology and Risk Factors Aetiology Acute mesenteric ischemia can result from occlusion of a mesenteric vessel arising from an embolus, which may emanate from an atheroma of the aorta or cardiac mural thrombus, or from primary thrombosis of a mesenteric vessel, usually at a site of atherosclerotic stenosis. Embolic occlusion is more common in the…

Behçet’s Disease

Overview Behçet’s syndrome is a chronic, relapsing, multisystem inflammatory disorder and variable-vessel vasculitis characterized classically by recurrent oral ulcers, genital ulcers, ocular inflammation, and skin lesions. It can also involve the joints, vessels, nervous system, and gastrointestinal tract.  The disease is most prevalent along the historic “Silk Road” region, including Turkey, the Middle East, and…

Leukaemia

Overview  Leukemia is a common malignancy in children and adults that occurs when alterations in normal cell regulatory processes cause uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Leukaemia:  Clonal proliferation of hematopoietic stem cells in the bone marrow Acute Leukaemia:  Clonal proliferation of hematopoietic stem cells in the bone marrow that develops…

Goodpasture Syndrome (Anti-GBM disease)

Overview Goodpasture syndrome, now more precisely termed anti-glomerular basement membrane (anti-GBM) disease , is a rare autoimmune small-vessel vasculitis affecting lungs and kidneys, typically manifesting with diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis.  Microscopic polyangiitis (MPA) has an estimated incidence of approximately 0.5 to 1.8 cases per million per year. It demonstrates a bimodal age…

Takayasu Arteritis 

Overview Takayasu arteritis is a rare, chronic large-vessel vasculitis primarily affecting the aorta and its major branches, leading to stenosis, occlusion, or aneurysm formation. It most commonly affects young women (<40 years), particularly of Asian descent. The global incidence is estimated at 1–2 per million per year, with a female predominance (F:M ~9:1). It is…

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