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Archives: Diseases

Sickle Cell Anaemia

Overview Sickle cell anaemia is an autosomal recessive disorder causing production of abnormal ß-globin chains. A single amino acid is substituted in the ß-globin chain (Glu to Val at position…
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Acute Kidney Injury (AKI)

Overview Acute kidney injury (AKI) (formerly acute renal failure) is the syndrome arising from a rapid fall in GFR (over hours to days). It is characterized by retention of both…
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Spondylarthropathy

Overview  The spondyloarthropathies are a diverse group of inflammatory arthritides that share certain genetic predisposing factors and clinical features. Their most characteristic feature is inflammatory back pain. Enthesitis, another characteristic feature,…
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Rheumatoid Arthritis

Overview Rheumatoid arthritis is a common systemic inflammatory disease characterized by the presence of a destructive polyarthritis with a predisposition for affecting the small joints of the hands and feet and…
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Polymyalgia Rheumatica (PMR)

Overview Polymyalgia rheumatica is a common inflammatory condition affecting older adults, typically over 50 years of age, characterised by pain and stiffness in the shoulder and pelvic girdles. It is…
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Genital Prolapse

Overview Pelvic organ prolapse is a condition in which pelvic organs abnormally descend or herniate from their normal attachment sites or their normal position in the pelvis to or beyond the…
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Urinary Incontinence

Overview Urinary incontinence is an important condition because it causes significant distress. Approximately 15% of the general female adult population have a significant problem with urinary incontinence. Anatomy and Physiology…
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Menopause

Overview The menopause means the final menstrual period – diagnosed retrospectively after one year of amenorrhoea. Cessation occurs due to loss of ovarian function. The “declining oocyte pool” theory states that…
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Acute Lymphoblastic Leukaemia

Overview Acute Lymphoblastic Leukaemia (ALL) is a malignancy of lymphoid cells. The two main ALL is T-cells ALL and B-cells ALL. In ALL there is uncontrolled proliferation of immature lymphoblasts in…
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Leukaemia

Overview  Leukemia is a common malignancy in children and adults that occurs when alterations in normal cell regulatory processes cause uncontrolled proliferation of hematopoietic stem cells in the bone marrow.…
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