Armando Hasudungan
Biology and Medicine videos

Neonatal Conditions

Vitals

For more information: Parturition and Routine Care 

NORMAL EXPECTED PHYSIOLOGICAL VALUES AT DIFFERENT AGES
Age (years) Respiratory Rate Heart rate Systolic Blood Pressure 
<1 30-40 110-160 70-90
1-2 25-35 100-150 80-95
2-5 25-30 95-140 80-100
5-12 20-25 80-120 90-110
>12 15-20 60-100 100-120

Oxygen saturation return to 100% after 10 minutes post partum.

Prematurity

RISK FACTORS FOR PREMATURE BABY
Maternal Fetal
  • Previous preterm birth
  • Extremes of materal age
  • Low pre-pregnant weight
  • Gestational diabetes
  • Acute illness during pregnancy
  • Cervical incompetence
  • Pre-eclampsia/ eclampsia
  • In vitro fertilization
  • Multiple gestation
  • Fetal anomalies
  • Polyhydramnios
  • Fetal demise
  • First trimesters threatened abortion
Placental Social
  • Placenta praevia
  • Placental abruption
  • Premature rupture of membrane
  • Chorioaminonitis
  •  Smoking
  • Alcohol use
  • Illicit drug use
  • Heavy physical work
  • Stress
  • Low socioeconomic status
Remember All pregnant women between 24 and 34 weeks at risk of preterm birth should be offered treatment with a single course of antenatal corticosteroids to promote lung development (induction of type II pneumocytes)

Follow the neonatal resuscitation guideline in needed.


 

Short Term Complication of Prematurity
Respiratory Respiratory Distress syndrome
Apnea
Cardiac Patetent ductus arteriosus
Neurological Intraventricular haemorrhage
Periventricular leukomalacia
Hepatic Hypoglycemia
Hyperglycemia
Hyperbilirubinaemia
Renal Immature kidney
Gastrointestinal Feeding problems
Necrotizing enterocolitis
Haemotological Anaemia
Immunologial Infection

 

Long term complication of prematurity
Delayed Growth
Retinopathy
Chronic lung disease
Neurodevelopment delay

Jaundice

Remember Jaundice <24hours is abnormal (pathological) and >24 is often normal

Jandice is common in the newborn (50%) and is almost always caused by unconjugated bilirubin. Hyperbilirubinemia can lead to kernicterus (brain damage)

  • Jaundice in the first 24 hours is abnormal and should be investigated. Consider:
  • Jaundice after 24 hours is normal due to the haemoglobin being broken down slowly. Neonates do not need as much heamoglobin as it did in the uterus.
  • Prolonged jaundice (~14 days), determine if hyperbilirubinemia is conjugated or unconjugated.
    • Unconjugated bilirubinema – hypothyroidism, infection and G6PD
    • Conjugated bilirubinema is uncommon and always pathological – biliary atresia, neonatal hepatitis.

Management for Jaundice after 24hours

  • Phototherapy uses light to convert bilirubin to soluble products that can be excreted without conjugation
  • Get them to poo
  • Exchange transfusion
Watch Bilirubin Metabolism
Screen Shot 2016-04-20 at 12.08.37 AM

Bilirubin Pathway

Respiratory Distress

Respiratory distress is common immediately after birth, and is typically caused by abnormal respiratory function during the transition from fetal to neonatal life

Sign and symptoms

  • Increased WOB
  • Tachypnoea (>40bpm)
  • Expriatory grunt
  • Central cynosis

Persistent Pulmonary hypertension: With the first breath pulmonary vascular resistance falls and there is a rush of blood to the lungs. This process is partly mediated by nitric oxide and initiates the change from fetal to adult circulation. This process may be interrupted in various conditions (RDS, TTN, meconium aspiration, etc), and as a result pulmonary hypertension develops.

Abnormal persistence of elevated pulmonary vascular resistance that leads to right-to-left shunting of deoxygenated blood through the foramen ovale and the ductus arteriosus, resulting in hypoxemia.

 

Respiratory Distress Syndrome or “hylane membrane disease” is caused by deficiency of surfactant, the phospholipid mixture that reduces alveolar surface tension, which decreases the pressure needed to keep the alveoli inflated, and maintains alveolar stability. When surfactant is deficient it can lead to atelectasis, re-inflation with each breath exhausts the baby, and respiratory failure follows. Bronchopulmonary dysplasia can further complicate things premature infants with RDS. Bronchopulmonary dysplasia persistent hypoxia +/- difficult ventilator weaning.

More info on RDS

Transient Tachypnoea of Neonate or “wet lung syndrome”  is caused by failure of adequate lung fluid clearance at birth, resulting in excess lung liquid. The liquid fills the air spaces and moves into the extra-alveolar interstitium, where it pools in perivascular tissues and interlobar fissures until it is cleared by the lymphatic or vascular circulation.

Remember Common in term infant delivered by Cesarean section or rapid second stage labor. Rapid improvement generally within hours to a few days.

Pneumonia (GBS or e-coli)

Meconium aspiration syndrome occurs in the term/near term infant when meconium, the faecal material that accumulates in the fetal colon during gestation, is passed in utero, leading to meconium obtained amniotic fluid. It may lead to airway obstruction, surfactant dysfunction, pulmonary vasoconstriction, infection and chemical pneumonitis.

Remember Chest X- ray may reveal patchy infiltrates, increase AP diametes, flattening of diagphragm

Pneumothorax

Apnoea is a common problem until about 24 weeks gestation. Management with CPAP and close monitoring.

Unwell child - Sepsis

Sepsis should always be a differential diagnosis in an unwell child.

sepsis SANDS

Signs and symptoms of an unwell child, including sepsis

Aetiology and Management:

  • Early onset infection: Group B Streptococcus or E-coli. Penicillins (ie. Benzypenicillin) and Gentamicin a safe combination for most neonates.
  • Late onset infection: Staphlococcus spp. and Listeria. Penicillins (ie. Ampicillin) and gentamicin.

More info on Paediatric Sepsis

Remember Most common organisms in the neonate are group B streptococcus, E. coli and listeria monocytogenes

 

Watch: Neonatal Infections Overview

Dermatology

Normal Abnormal
Naevus flammeus
Milia
Miliaria
Erythema toxicum
Mongolian blue spot

Gastrointestinal and Surgery

Vomiting is normal. However, bilious (green) vomiting in neonates always needs urgent help or prompt investigation and management

Necrotising enterocolitis is an inflammatory bowel necrosis. Prematurity is a major risk factor. Perforated NEC associated with 40% mortality in neonates

necrotising entero

Nectrotising enterocolitis

Gastroenteritis

acutegastro

Gastroenterocolitis

Bowel Obstruction: Malrotation, volvulus, intussusception, duodenal atresia (associated with Down’s syndrome), Meconium ileus (associated with cystic fibrosis)

Pyloric stenosis: Hypertrophy of the pyloric smooth muscle in early infancy, which occurs at about 3-6 weeks causing classical projectile vomiting after meals.

PS

Pyloric stenosis Projectile vomiting of food/liquid minutes after eating

Hurschrung’s disease: Congenital absence of ganglia in a segment of colon leading to functional GI obstruction, constipation and megacolon.

hirscburngs

Hurschrung’s disease typically effects the distal colon, sigmoid/rectum and causes dysmotility leading to a non-mechanical obstruction.

Congenital diaphragmatic hernia: a developmental defect in the diaphragm allowing herniation of abdominal contents into the chest. This leads to impaired lung development (pulmonary hyperplasia and hypertension).

Congenital Dhernia

Congenital diaphragmatic hernia

Oesophageal atresia and Tracheo-oseophageal fistula is a spectrum of abnormalities with Oseophageal atresia plus a distal Tacheo-oesophageal fistula being the most common (86%).

Inguinal Hernias are due to patent processus vaginalis (the passage which ushers the descending testicle into the scrotum). Require prompt surgical referral as the frequently strangulate.

Abdominal wall (umbilical) defects

  • Gastroschisis
  • Exomphalos (omphalocele)
congenital hernia

Abdominal wall (umbilical) defects

Genitourinary

Undescended testis (cryptochidism) testicular descent from the fetal abdominal site into the scrotum is normally complete by birth. Absence of a scrotal testis may be due to agenesis, intrabdominal arrest, incomplete descent, or ectopic descent. Incidence of 2-4% in newborn. Commoner on the right sire.

Posterior urethral valve presents with oligohydramnios or absent or feeble voiding (+/- uraemia and a palpable bladder).

Congenital/genetic disorders

  • Horseshoe Kidney
  • infantile polycystic kidney disease
  • Ectopic kidney
  • Patent urachus
  • Renal agenesis

Foreskin

  • Balanitis – infection/inflammation under the foreskin can include the penile shaft. Circumcision is indicated if topical steroids/antibiotic do not work.
  • Hypospadias – narrow meatus on ventral penis
  • Epispadias – meatus on dorsum of penis
  • Phimosis – a non-retractable foreskin with associated scarring that will not resolve spontaneously. Circumcision is required
  • Paraphimosis – Foreskin can not be returned over the glands penis.

Scrotal swelling

  • Hydrocele – congenital fluid filled processus vaginalis and tunica vaginalis
  • Varicocele – due to dilated papiniform venous plexus of the spermatic cord (usual onset after puberty)

Cardiovascular

Congenital Heart Disease

Cynotic (right to left shunt – remember the 5T’s)

  • Tetralogy of Fallot
  • Transposition of the Great vessels
  • Truncus arteriosis
  • Total anomalous pulmonary venous return
  • Tricuspid Artresia
  • Hypoplastic left heart syndrome

Acynotic (Left to right shunt – remember the 3Ds)

  • Patent Ductus Arterioses
  • Atrial-septal Defect
  • Ventral-septal Defect
  • Coarctation of the Aorta
  • Pulmonary hypertension

Cardiovascular Infection

  • Myocarditis
  • Endocarditis

Neurology

Seizures Febrile Seizure and Epilepsy classify seizures differently.

Classification

  • Febrile Seizures
    • Simple Seizure (Generalised Seizures)
    • Complex Seizure (Partial or Generalised Seizures)
    • Status Epilepticus (prolonged continuous seizure 30min+)
  • Non Febrile Seizures (Epilepsy)
    • Partial (Focal) Seizures
      • Simple partial
      • Complex partial
    • Generalised Seizures
    • Status Epilepticus (prolonged continuous seizure 30min+)
  • Non Febrile Seizures – Other causes (VITAMIN)
    • Vascular – Hypoxic-Ischaemic encephalopathy
    • Infection – Meningitis/Encephalitis
    • Temperature – Febrile Seizure
    • Abnormality of the CNS
    • Metabolic Disturbance – Hypoglycemia, Hypocalcemia, Hypomagnesiumea, Hyper/Hyponaturemia
    • Intracranial Haemorrhage/infarction
    • Neoplastic or CNS lesion

Management (Anticonvulsants)

  • Phenyobarbitone
  • Phenytoin
  • Benzo’s

More info on Paediatric Seizures


Neural Tube Defect

Neural tube defects (NTDs) result from failure of the neural tube to close between the 3rd and 4th week of in utero development.

NTDs are the second most common congenital anomaly after congenital heart defects.

NTDs of the spinal cord (most common)

  • Open Spina Bifida (not covered by skin)
  • Closed Spina Bifida (covered by skin)
  • Spina Bifida Occulta (skin covered with no visible abnormalities of the back)

NTDs of the brain

NTDs of both the brain and spinal cord


Cerebral Palsy

More information on cerebral palsy


Hydrocephalus is an abnormal excess of CSF in the ventricular system of the brain.

More info on Hydrocephalus

Genetic Disease

  • Down’s Syndrome
  • Edward’s Syndrome
  • Klinfelter’s Syndrome
  • Patau’s Syndrome
  • Turner’s Syndrome
  • Duchenne Muscular Dystrophy
  • Infantile polycysitc kidney disease
  • Fragile X
  • Cystic Fibrosis
  • B-thalassemia

Birth Defects

Common Birth Defects

  • Congenital Heart defect
  • Development hip dysplasia
  • Hypospadias
  • Talipes equinovarus
  • Hypertrophic pyloric stenosis
  • Down syndrome
  • Cleft lip/palateSpina bifida
  • Tracheo-eosphageal fistula
  • Abdominal wall defect (Exomphalos and gastroschisis)

More info on Birth Defects

TORCH

Most Transplacental Intrauterine Infections are acquired in first of second trimester.

TORCH

  • Toxoplasmosis
  • Other: Syphillis and Varicella
  • Rubella
  • Cytomegalovirus (CMV
  • Herpes Simplex

More info on Infectious Disease in Pregnancy

Resuscitation

For more info on resuscitation of the newborn

Resus pathway

Neonate Resuscitation Pathway